public class Program
   {
      private const string SerialPortId = "COM6";

      private const string AppKey = "................................";
      private const string AppEui = "................";

      private const byte MessagePort = 15;

      //private const string Payload = "48656c6c6f204c6f526157414e"; // Hello LoRaWAN
      private const string Payload = "01020304"; // AQIDBA==
      //private const string Payload = "04030201"; // BAMCAQ==

   public static void Main()
   {
      SerialDevice serialDevice;
      uint bytesWritten;
      uint txByteCount;
      uint bytesRead;

      Debug.WriteLine("devMobile.IoT.SeeedLoRaE5.NetworkJoinOTAA starting");

      Debug.WriteLine($"Ports available: {Windows.Devices.SerialCommunication.SerialDevice.GetDeviceSelector()}");

      try
      {
         serialDevice = SerialDevice.FromId(SerialPortId);

         // set parameters
         serialDevice.BaudRate = 9600;
         serialDevice.Parity = SerialParity.None;
         serialDevice.StopBits = SerialStopBitCount.One;
         serialDevice.Handshake = SerialHandshake.None;
         serialDevice.DataBits = 8;

         serialDevice.ReadTimeout = new TimeSpan(0, 0, 5);
         serialDevice.WriteTimeout = new TimeSpan(0, 0, 4);

         DataWriter outputDataWriter = new DataWriter(serialDevice.OutputStream);
         DataReader inputDataReader = new DataReader(serialDevice.InputStream);

         // set a watch char to be notified when it's available in the input stream
         serialDevice.WatchChar = '\n';

         // clear out the RX buffer
         bytesRead = inputDataReader.Load(128);
         while (bytesRead > 0)
         {
            string response = inputDataReader.ReadString(bytesRead);
            Debug.WriteLine($"RX :{response}");

            bytesRead = inputDataReader.Load(128);
         }

         // Set the Region to AS923
         bytesWritten = outputDataWriter.WriteString("AT+DR=AS923\r\n");
         Debug.WriteLine($"TX: region {outputDataWriter.UnstoredBufferLength} bytes to output stream.");
         txByteCount = outputDataWriter.Store();
         Debug.WriteLine($"TX: {txByteCount} bytes via {serialDevice.PortName}");

         // Read the response
         bytesRead = inputDataReader.Load(128);
         if (bytesRead > 0)
         {
            String response = inputDataReader.ReadString(bytesRead);
            Debug.WriteLine($"RX :{response}");
         }

         // Set the Join mode
         bytesWritten = outputDataWriter.WriteString("AT+MODE=LWOTAA\r\n");
         Debug.WriteLine($"TX: mode {outputDataWriter.UnstoredBufferLength} bytes to output stream.");
         txByteCount = outputDataWriter.Store();
         Debug.WriteLine($"TX: {txByteCount} bytes via {serialDevice.PortName}");

         // Read the response
         bytesRead = inputDataReader.Load(128);
         if (bytesRead > 0)
         {
            string response = inputDataReader.ReadString(bytesRead);
            Debug.WriteLine($"RX :{response}");
         }

         // Set the appEUI
         bytesWritten = outputDataWriter.WriteString($"AT+ID=AppEui,\"{AppEui}\"\r\n");
         Debug.WriteLine($"TX: AppEui {outputDataWriter.UnstoredBufferLength} bytes to output stream.");
         txByteCount = outputDataWriter.Store();
         Debug.WriteLine($"TX: {txByteCount} bytes via {serialDevice.PortName}");

         // Read the response
         bytesRead = inputDataReader.Load(128);
         if (bytesRead > 0)
         {
            String response = inputDataReader.ReadString(bytesRead);
            Debug.WriteLine($"RX :{response}");
         }

         // Set the appKey
         bytesWritten = outputDataWriter.WriteString($"AT+KEY=APPKEY,{AppKey}\r\n");
         Debug.WriteLine($"TX: AppKey {outputDataWriter.UnstoredBufferLength} bytes to output stream.");
         txByteCount = outputDataWriter.Store();
         Debug.WriteLine($"TX: {txByteCount} bytes via {serialDevice.PortName}");

         // Read the response
         bytesRead = inputDataReader.Load(128);
         if (bytesRead > 0)
         {
            String response = inputDataReader.ReadString(bytesRead);
            Debug.WriteLine($"RX :{response}");
         }

         // Set the port number
         bytesWritten = outputDataWriter.WriteString($"AT+PORT={MessagePort}\r\n");
         Debug.WriteLine($"TX: port {outputDataWriter.UnstoredBufferLength} bytes to output stream.");
         txByteCount = outputDataWriter.Store();
         Debug.WriteLine($"TX: {txByteCount} bytes via {serialDevice.PortName}");

         // Read the response
         bytesRead = inputDataReader.Load(128);
         if (bytesRead > 0)
         {
            String response = inputDataReader.ReadString(bytesRead);
            Debug.WriteLine($"RX :{response}");
         }

         // Join the network
         bytesWritten = outputDataWriter.WriteString("AT+JOIN\r\n");
         Debug.WriteLine($"TX: join {outputDataWriter.UnstoredBufferLength} bytes to output stream.");
         txByteCount = outputDataWriter.Store();
         Debug.WriteLine($"TX: {txByteCount} bytes via {serialDevice.PortName}");

         // Read the response, need loop as multi line response
         bytesRead = inputDataReader.Load(128);
         while (bytesRead > 0)
         {
            String response = inputDataReader.ReadString(bytesRead);
            Debug.WriteLine($"RX :{response}");

            bytesRead = inputDataReader.Load(128);
         }

         while (true)
         {
            bytesWritten = outputDataWriter.WriteString($"AT+MSGHEX=\"{Payload}\"\r\n");
            Debug.WriteLine($"TX: send {outputDataWriter.UnstoredBufferLength} bytes to output stream.");

            txByteCount = outputDataWriter.Store();
            Debug.WriteLine($"TX: {txByteCount} bytes via {serialDevice.PortName}");

            // Read the response, need loop as multi line response
            bytesRead = inputDataReader.Load(128);
            while (bytesRead > 0)
            {
               String response = inputDataReader.ReadString(bytesRead);
               Debug.WriteLine($"RX :{response}");

               bytesRead = inputDataReader.Load(128);
            }

            Thread.Sleep(300000);
         }
      }
      catch (Exception ex)
      {
         Debug.WriteLine(ex.Message);
      }
}

The thread '<No Name>' (0x2) has exited with code 0 (0x0).
devMobile.IoT.SeeedE5.NetworkJoinOTAA starting
TX: DR 13 bytes
RX :+DR: AS923

TX: MODE 16 bytes
RX :+MODE: LWOTAA

TX: ID=AppEui 40 bytes
RX :+ID: AppEui, ..:..:.:.:.:.:.:.

TX: KEY=APPKEY 48 bytes
RX :+KEY: APPKEY ................................

TX: PORT 11 bytes
RX :+PORT: 1

TX: JOIN 9 bytes
RX :+JOIN: Start
+JOIN: NORMAL
+JOIN: Network joined
+JOIN: NetID 000013 DevAddr ..:..:..:..
+JOIN: Done

TX: MSGHEX 22 bytes
RX :+MSGHEX: Start
+MSGHEX: FPENDING
+MSGHEX: RXWIN1, RSSI -41, SNR 9.0
+MSGHEX: Done

TX: MSGHEX 22 bytes
RX :+MSGHEX: Start
+MSGHEX: Done